العربية
Dr Mahmoud Mohamed Said Shalaby
Biography
My name is Professor Mahmoud Mohamed Said. I earned my Bachelor degree in Biochemistry from the Faculty of Science, Biochemistry Department at Ain Shams University (Cairo, Egypt, 1995). I got my Master degree in Biochemistry from the Faculty of Science, Biochemistry Department at Ain Shams University (Cairo, Egypt, 2001). I earned my Doctor in Philosophy Degree in Biochemistry in collaboration between Faculty of Science, Biochemistry Department at Ain Shams University (Cairo, Egypt) and Department of Experimental Pathology and Tumor Biology, Nagoya City University Graduate School of Medical Sciences (Nagoya, Japan) in 2006. I got a postdoctoral scholarship to Nagoya City University Graduate School of Medical Sciences, Department of Experimental Pathology and Tumor Biology (Nagoya, Japan) in 2007. I got my Professorship degree in Biochemistry in 2018 (Supreme Council of Universities, Cairo, Egypt). My main research aims to understand molecular cell signaling related to experimental tumor biology and finding preventive or therapeutic modalities using either natural products or synthetic/semisynthetic compounds. Through collaboration with different research centers, many natural products were used, as prophylactic, preventive or therapeutic agents against different experimental diseases, such as liver injury, neurotoxicity, nephrotoxicity, hepatic encephalopathy, as well as tumors, both in vivo and in vitro. In addition, the use of nanotechnology and nanoparticles preparation for the treatment of cancer, both in vivo and in vitro, was investigated. The study for the role of microRNAs as diagnostic and predictive biomarkers for the diagnosis as well as response to therapy in different human cancers, including liver and breast, was also unveiled. My list of publications includes 49 articles published in International and National Journals.
Qualification
- Ph.D. in Biochemistry, Ain Shams University, Egypt-Nagoya City University Graduate School of Medical Sciences, Japan, 2006.
- MSc in Biochemistry, Ain Shams University, Egypt, 2001.
- BSc in Biochemistry, Ain Shams University, Egypt, 1995.
Teaching Interest
- Biochemistry
Research Interest
- Biochemistry
- Cancer Biology
- Toxicology
- Cell Signaling
Publications
- Said MM, Hokaiwado N, Tang M, Ogawa K, Suzuki S, Ghanem HM, Esmat AY, Asamoto M, Refaie FM, Shirai T Inhibition of prostate carcinogenesis in probasin/SV40 T antigen transgenic rats by leuprorelin, a luteinizing hormone-releasing hormone agonist. Cancer Science 2006; 97(6): 459-467.
- Said MM, Ogawa K, Pitchakarn P, Takahashi S, Asamoto M, Shirai T Cyclooxygenase 2 and prostaglandin E2 are not involved in N-nitrosodiethylamine-initiated early rat hepatocarcinogenesis. Journal of Toxicologic Pathology 2009; 22(4): 263-271.
- Said MM, Bosland MC The anti-inflammatory effect of montelukast, a cysteinyl leukotriene receptor-1 antagonist, against estradiol-induced nonbacterial inflammation in the rat prostate. Naunyn-Schmiedeberg’s Archives of Pharmacology 2017; 390(2): 197-205.
- Medhat AM, Azab KS, Said MM, El Fatih NM, El Bakary NM Antitumor and radiosensitizing synergistic effects of apigenin and cryptotanshinone against solid Ehrlich carcinoma in female mice. Tumor Biology 2017; 39(10): 1-13.
- Badiea EA, Sayed AA, Maged M, Fouad WM, Said MM, Esmat AY A novel thermostable and halophilic thioredoxin reductase from the Red Sea Atlantis II hot brine pool. PLoS ONE 2019; 14(5): e0217565.
- Ebrahim HM, El-Rouby MN, Morsy ME, Said MM, Ezz MK The synergistic cytotoxic effect of laser-irradiated gold nanoparticles and sorafenib against the growth of a human hepatocellular carcinoma cell line. Asian Pacific Journal of Cancer Prevention 2019; 20(11): 3369-3376.
- Ibrahim AM, Said MM, Hilal AM, Medhat AM, Abd Elsalam IM Candidate circulating microRNAs as potential diagnostic and predictive biomarkers for the monitoring of locally advanced breast cancer patients. Tumor Biology 2020; 42(10): 1010428320963811.doi:10.1177/ 1010428320963811.
- Baraka SM, Saleh DO, Ghaly NS, Melek FR, Gamal el Din AA, Khalil WKB, Said MM, Medhat AM Flavonoids from Barnebydendron riedelii leaf extract mitigate thioacetamide-induced hepatic encephalopathy in rats: The interplay of NF-κB/IL-6 and Nrf2/HO-1 signaling pathways. Bioorganic Chemistry 2020; 105: 104444.
- Sayed HM, Said MM, Morcos NYS, El Gawish MA, Ismail AM Antitumor and radiosensitizing effects of zinc oxide-caffeic acid nanoparticles against solid Ehrlich carcinoma in female mice. Integrative Cancer Therapies 2021; 20:1-22.
- Abdel-Moniem MM, Hassan AM, Said MM, Esmat AY Iron supplementation ameliorates aloin-induced iron deficiency anemia in rats. Experimental and Molecular Pathology 2022; 124: 104740.
- Ahmed EK, El-Gendy AK, El-Tantawi H, El-Rouby MN, Said MM, Ghanem HM, Esmat AY Autophagy in antitumor activity of aloin for breast cancer cells compared with doxorubicin. Indian Journal of Experimental Biology 2023; 61: 252-264.
- Mohamed MM, Rashed LA, El-Boghdady NA, Said MM Bone marrow-derived mesenchymal stem cells and pioglitazone or exendin-4 synergistically improve insulin resistance via multiple modulatory mechanisms in high-fat diet/streptozotocin-induced diabetes in rats. Reports of Biochemistry & Molecular Biology 2023:12(1): 42-58.